Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2

Written by: Akshay S. Thomas, MD October 2019 Chew EY, Clemons TE, Jaffe GJ, et al. Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2: A Randomized Clinical Trial. Ophthalmology. 2019;126(4):540-549. Macular telangiectasia type 2 (MacTel 2) is an idiopathic condition without available treatment options which results in slowly […]

Clinical Effectiveness of Intravitreal Therapy With Ranibizumab vs. Aflibercept vs. Bevacizumab for Macular Edema Secondary to Central Retinal Vein Occlusion: A Randomized Clinical Trial by the LEAVO Study Group

Written by: Avni P. Finn, MD October 2019 Hykin P, Prevost AT, Vasconcelos JC, et al. Clinical Effectiveness of Intravitreal Therapy With Ranibizumab vs Aflibercept vs Bevacizumab for Macular Edema Secondary to Central Retinal Vein Occlusion: A Randomized Clinical Trial. JAMA Ophthalmol. Published online August 29, 2019. doi:10.1001/jamaophthalmol.2019.3305 Visual impairment in central retinal vein occlusion (CRVO) due to […]

Rhegmatogenous Retinal Detachment in Children: Clinical Factors Predictive of Successful Surgical Repair

Written by: Vlad Matei, MD October 2019 Smith JM, Ward LT, Townsend JH, et al. Rhegmatogenous retinal detachment in children: clinical factors predictive of successful surgical repair. Ophthalmology 2019;126:1263-1270. The literature devoted to pediatric rhegmatogenous retinal detachment (RRD) is relatively scarce, but we know that RRD in children is potentially more challenging to manage than […]

Phenotypic Spectrum of Pentosan Polysulfate Sodium–Associated Maculopathy: A Multicenter Study

Written by: Joshua D. Levinson, MD September 2019 Adam M. Hanif, MD; Stephen T. Armenti, MD, PhD; Stanford C. Taylor, MD, et al. Phenotypic Spectrum of Pentosan Polysulfate Sodium–Associated Maculopathy A Multicenter Study. JAMA Ophthalmol. Sept 2019. Pentosan polysulfate sodium (brand name: Elmiron) is used to treat interstitial cystitis (IC), a chronic pain syndrome of […]

HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration

Written by: Christopher Aderman, MD September 2019 Pravin U. Dugel, MD, Adrian Koh, MD, FRCS, Yuichiro Ogura, MD, Glenn J. Jaffe, MD, Ursula Schmidt-Erfurth, MD, David M. Brown, MD, Andre V. Gomes, MD, PhD, James Warburton, MBBS, Andreas Weichselberger, PhD, Frank G. Holz, MD, on behalf of the HAWK and HARRIER Study Investigators. Ophthalmology. 2019 Apr 12. […]

Subthreshold Nanosecond Laser Intervention in Age-Related Macular Degeneration

Written by: Brian K. Do, MD September 2019 Guymer RH, Wu Z, Hodgson LA, et al. Subthreshold Nanosecond Laser Intervention in Age-Related Macular Degeneration: The LEAD Randomized Controlled Clinical Trial. Ophthalmology. 2019 Jun;126(6):829-838. doi: 10.1016/j.ophtha.2018.09.015. Epub 2018 Sep 20. Rosenfeld PJ, Feuer WJ. Warning: Do not Treat Intermediate AMD with Laser Therapy. Ophthalmology. 2019 Jun;126(6):839-840. doi: 10.1016/j.ophtha.2018.12.016. […]

The Port Delivery System with Ranibizumab for nAMD: Results from the Phase 2 LADDER Study

Written by: Joshua D. Levinson, MD September 2019 Campochiaro PA, Marcus DM, Awh CC, et al. The Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration: Results from the Randomized Phase 2 Ladder Clinical Trial. Ophthalmology. 2019 Aug;126(8):1141-1154 Intravitreal anti-vascular endothelial growth factor (VEGF) therapy has revolutionized the treatment of neovascular age-related macular degeneration […]

FLUID Study 24-Month Results: Tolerating Subretinal Fluid in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab Using a Treat-and-Extend Regimen

Written by: Christopher Aderman, MD August 2019 Robyn H. Guymer, MBBS, PhD, Caroline M. Markey, PhD, Ian L. McAllister, MBBS, PhD, Mark C. Gillies, MBBS, PhD, Alex P. Hunyor, MBBS, Jennifer J. Arnold, MBBS, on behalf of the FLUID Investigators. Ophthalmology. Volume 126, Number 5, May 2019 Analysis of the CATT, VIEW, and HARBOR studies […]