HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration

Written by: Christopher Aderman, MD September 2019 Pravin U. Dugel, MD, Adrian Koh, MD, FRCS, Yuichiro Ogura, MD, Glenn J. Jaffe, MD, Ursula Schmidt-Erfurth, MD, David M. Brown, MD, Andre V. Gomes, MD, PhD, James Warburton, MBBS, Andreas Weichselberger, PhD, Frank G. Holz, MD, on behalf of the HAWK and HARRIER Study Investigators. Ophthalmology. 2019 Apr 12. […]

Subthreshold Nanosecond Laser Intervention in Age-Related Macular Degeneration

Written by: Brian K. Do, MD September 2019 Guymer RH, Wu Z, Hodgson LA, et al. Subthreshold Nanosecond Laser Intervention in Age-Related Macular Degeneration: The LEAD Randomized Controlled Clinical Trial. Ophthalmology. 2019 Jun;126(6):829-838. doi: 10.1016/j.ophtha.2018.09.015. Epub 2018 Sep 20. Rosenfeld PJ, Feuer WJ. Warning: Do not Treat Intermediate AMD with Laser Therapy. Ophthalmology. 2019 Jun;126(6):839-840. doi: 10.1016/j.ophtha.2018.12.016. […]

The Port Delivery System with Ranibizumab for nAMD: Results from the Phase 2 LADDER Study

Written by: Joshua D. Levinson, MD September 2019 Campochiaro PA, Marcus DM, Awh CC, et al. The Port Delivery System with Ranibizumab for Neovascular Age-Related Macular Degeneration: Results from the Randomized Phase 2 Ladder Clinical Trial. Ophthalmology. 2019 Aug;126(8):1141-1154 Intravitreal anti-vascular endothelial growth factor (VEGF) therapy has revolutionized the treatment of neovascular age-related macular degeneration […]

FLUID Study 24-Month Results: Tolerating Subretinal Fluid in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab Using a Treat-and-Extend Regimen

Written by: Christopher Aderman, MD August 2019 Robyn H. Guymer, MBBS, PhD, Caroline M. Markey, PhD, Ian L. McAllister, MBBS, PhD, Mark C. Gillies, MBBS, PhD, Alex P. Hunyor, MBBS, Jennifer J. Arnold, MBBS, on behalf of the FLUID Investigators. Ophthalmology. Volume 126, Number 5, May 2019 Analysis of the CATT, VIEW, and HARBOR studies […]

Safety of 6000 Intravitreal Dexamethasone Implants

Written by: Katherine E. Talcott, MD Rajesh B, Zarranz-Ventura J, Fung AT et al. Safety of 6000 intravitreal dexamethasone implants. Br J Ophthalmol. 2019 April 30. [Epub ahead of print] Corticosteroids, including the intravitreal dexamethasone implant, are used to treat macular edema from multiple etiologies. Clinical trials have revealed an increase in IOP and cataract […]

Non-supine Positioning after Macular Hole Surgery

Written by: Katherine E. Talcott, MD Lindtjorn B, Krohn J Austeng D et al. Nonsupine positioning after macular hole surgery: a prospective multicenter study. Ophthalmol Retina. 2019 May;3(5):388-92. Macular hole (MH) surgical repair typically involves the release of tangential traction on the retina by lifting the hyaloid, removal of the internal limiting membrane, epiretinal membrane, […]