Category: Journal Club

Written by: Rehan M. Hussain, MD November 2019 Maguire, AM, Russell S, Wellman JA. Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation-Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials. Ophthalmology 2019 Sep;126(9):1273-1285.  doi: 10.1016/j.ophtha.2019.06.017. Published online Jun 22, 2019. Voretigene neparvovec (VN) is a non-replicating adeno-associated virus (AAV), which has […]

Written by: Mohsin H. Ali, MD October 2019 Rizzo S, Caporossi T, Tartaro R, Finocchio L, Franco F, Barca F, et al. A Human Amniotic Membrane Plug to Promote Retinal Breaks Repair and Recurrent Macular Hole Closure. Retina 2019;39. Chronic, large macular holes that are refractory to initial, conventional surgical approaches (e.g. pars plana vitrectomy, […]

Written by: Akshay S. Thomas, MD October 2019 Chew EY, Clemons TE, Jaffe GJ, et al. Effect of Ciliary Neurotrophic Factor on Retinal Neurodegeneration in Patients with Macular Telangiectasia Type 2: A Randomized Clinical Trial. Ophthalmology. 2019;126(4):540-549. Macular telangiectasia type 2 (MacTel 2) is an idiopathic condition without available treatment options which results in slowly […]

Written by: Avni P. Finn, MD October 2019 Hykin P, Prevost AT, Vasconcelos JC, et al. Clinical Effectiveness of Intravitreal Therapy With Ranibizumab vs Aflibercept vs Bevacizumab for Macular Edema Secondary to Central Retinal Vein Occlusion: A Randomized Clinical Trial. JAMA Ophthalmol. Published online August 29, 2019. doi:10.1001/jamaophthalmol.2019.3305 Visual impairment in central retinal vein occlusion (CRVO) due to […]

Written by: Vlad Matei, MD October 2019 Smith JM, Ward LT, Townsend JH, et al. Rhegmatogenous retinal detachment in children: clinical factors predictive of successful surgical repair. Ophthalmology 2019;126:1263-1270. The literature devoted to pediatric rhegmatogenous retinal detachment (RRD) is relatively scarce, but we know that RRD in children is potentially more challenging to manage than […]

Written by: Joshua D. Levinson, MD September 2019 Adam M. Hanif, MD; Stephen T. Armenti, MD, PhD; Stanford C. Taylor, MD, et al. Phenotypic Spectrum of Pentosan Polysulfate Sodium–Associated Maculopathy A Multicenter Study. JAMA Ophthalmol. Sept 2019. Pentosan polysulfate sodium (brand name: Elmiron) is used to treat interstitial cystitis (IC), a chronic pain syndrome of […]

Written by: Christopher Aderman, MD September 2019 Pravin U. Dugel, MD, Adrian Koh, MD, FRCS, Yuichiro Ogura, MD, Glenn J. Jaffe, MD, Ursula Schmidt-Erfurth, MD, David M. Brown, MD, Andre V. Gomes, MD, PhD, James Warburton, MBBS, Andreas Weichselberger, PhD, Frank G. Holz, MD, on behalf of the HAWK and HARRIER Study Investigators. Ophthalmology. 2019 Apr 12. […]

Written by: Brian K. Do, MD September 2019 Guymer RH, Wu Z, Hodgson LA, et al. Subthreshold Nanosecond Laser Intervention in Age-Related Macular Degeneration: The LEAD Randomized Controlled Clinical Trial. Ophthalmology. 2019 Jun;126(6):829-838. doi: 10.1016/j.ophtha.2018.09.015. Epub 2018 Sep 20. Rosenfeld PJ, Feuer WJ. Warning: Do not Treat Intermediate AMD with Laser Therapy. Ophthalmology. 2019 Jun;126(6):839-840. doi: 10.1016/j.ophtha.2018.12.016. […]